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Narrowing of an artery The tissues distal to the narrow point become ischaemic. The cells may receive enough blood to meet their minimum needs, but not enough to cope with an increase in metabolic rate, e.g. when muscle activity is increased. This causes acute cramp-like ischaemic pain, which disappears when exertion stops. Cardiac muscle and skeletal muscles of the lower limb are most commonly affected. Ischaemic pain in the heart is called angina pectoris (p. 120), and in the lower limbs, intermittent claudication. Occlusion of an artery When an artery is completely blocked, the tissues it supplies rapidly undergo degeneration and die from ischaemia, which leads to infarction. If a major artery supplying a large amount of tissue is affected, the consequences are likely to be more severe than if the obstruction occurs in a minor vessel. If the tissue is well provided with a collateral circulation (such as the circulus arteriosus provides in the brain), tissue damage is less t...