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What is Negative Feedback Mechanisms ? In human body systems controlled by negative feedback, the effector response decreases or negates the effect of the original stimulus, maintaining or restoring homeostasis (thus the term negative feedback). 1) Control of body temperature is similar to the non-physiological example of a domestic central heating system. 2) The thermostat (temperature detector) is sensitive to changes in room temperature (variable factor). 3) The thermostat is connected to the boiler control unit (control centre), which controls the boiler (effector). 4) The thermostat constantly compares the information from the detector with the preset temperature and, when necessary, adjustments are made to alter the room temperature. 5) When the thermostat detects the room temperature is low, it switches the boiler on. The result is output of heat by the boiler, warming the room. 6) When the preset temperature is reached, the ...