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What is spleen and what is importance of Spleen? Spleen The oval spleen is the largest single mass of lymphatic tissue in the body, measuring about 12 cm (5 in.) in length .It is located in the left hypochondriac region between the stomach and diaphragm. The superior surface of the spleen is smooth and convex and conforms to the concave surface of the diaphragm. Neighboring organs make indentations in the visceral surface of the spleen—the gastric impression (stomach), the renal impres- sion (left kidney), and the colic impression (left colic flexure of large intestine). Like lymph nodes, the spleen has a hilum. Through it pass the splenic artery, splenic vein, and efferent lymphatic vessels. A capsule of dense connective tissue surrounds the spleen and is covered in turn by a serous membrane, the visceral peritoneum. Trabeculae extend inward from the capsule. The capsule plus tra- beculae, reticular fibers, and fibroblasts constitute the stroma of the spleen; the p...